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Comparative antisecretory activity of several drugs in the gastric fistula squirrel monkey and rat
Research Communications in Chemical Pathology and Pharmacology
|July 1, 1977
Abstract:
A series of known antisecretory compounds, including glycopyrrolate, clonidine, propantheline bromide, CMN 131 (2-pyridylthiocetamide), and desmethylimipramine (DMI) were tested in the gastric fistula rat and monkey. The order of potency for inhibiting acid output was similar in both species. A general similarity exists in the responsiveness of the rat and monkey to gastric antisecretory agents. These data support the use of the squirrel monkey for assessment of gastric antisecretory activity.