Related Experiment Video
Updated: Jun 19, 2026
05:36
Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
Published on: October 4, 2024
Oral contraceptive pill for primary dysmenorrhoea
Chooi L Wong1, Cindy Farquhar, Helen Roberts
1O & G, FMHS, Auckland, New Zealand.
The Cochrane Database of Systematic Reviews
|October 13, 2009
Summary
Combined oral contraceptive pills (OCPs) offer pain relief for dysmenorrhoea, though evidence is limited. Further research is needed to compare OCPs with other treatments and different OCP formulations.
Area of Science:
- Reproductive Health
- Pharmacology
Background:
- Dysmenorrhoea, characterized by painful menstrual cramps, is a prevalent condition affecting many women.
- Combined oral contraceptive pills (OCPs) are frequently recommended for managing primary dysmenorrhoea.
Purpose of the Study:
- To evaluate the efficacy and safety of combined OCPs in managing primary dysmenorrhoea.
Main Methods:
- A systematic review of randomized controlled trials (RCTs) was conducted using multiple electronic databases.
- Included RCTs compared combined OCPs against placebo, no treatment, other OCPs, or nonsteroidal anti-inflammatory drugs (NSAIDs).
Main Results:
- Seven RCTs involving 497 women indicated that combined OCPs provided pain relief compared to placebo (OR 2.01).
- Sensitivity analysis confirmed OCP benefit, reducing heterogeneity. Adverse effects like nausea and headaches were reported but not statistically significant compared to placebo.
- No studies compared OCPs with NSAIDs; limited evidence suggested potential benefit of third-generation progestagens over second-generation OCPs.
Conclusions:
- Limited evidence supports the use of combined OCPs for pain improvement in dysmenorrhoea.
- No significant differences were found between various combined OCP preparations.
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