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Related Experiment Video

Updated: Jun 19, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Interventions for HIV-associated nephropathy.

Ismail Yahaya¹, Abdulrahman Olalekan Uthman, Muhammed Mubashir B Uthman

¹a) WMHTAC, Public Health, Epidemiology & Biostatistics, University of Birmingham, Birmingham, UK, b) Save The Youth Initiative, PO Box 3951, Kaduna North, Kaduna, Nigeria.

The Cochrane Database of Systematic Reviews

|October 13, 2009

Summary

No completed randomized controlled trials were found for human immunodeficiency virus-associated nephropathy (HIVAN) treatments. Observational studies suggest steroids and ACE inhibitors may benefit kidney function in HIVAN patients.

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Area of Science:

Nephrology
Infectious Diseases
Clinical Trials

Background:

Human immunodeficiency virus-associated nephropathy (HIVAN) is a leading cause of end-stage kidney disease (ESKD) in HIV-1 patients, particularly those of African descent.
HIVAN progresses rapidly to ESKD if left untreated, necessitating effective management strategies.
Current treatment goals include reducing HIV-1 replication and slowing chronic kidney disease progression, with various agents explored.

Purpose of the Study:

To evaluate the benefits and harms of adjunctive therapies for managing HIVAN.
To assess the impact of these therapies on symptom severity and all-cause mortality in HIVAN patients.

Main Methods:

A comprehensive search was conducted across multiple databases (CENTRAL, MEDLINE, EMBASE, AIDSearch) and other sources without language restrictions.
Inclusion criteria focused on randomized controlled trials (RCTs) and quasi-RCTs investigating any therapy for HIVAN.
Four relevant ongoing studies were identified, but no completed RCTs or quasi-RCTs met the inclusion criteria for this review.

Main Results:

No completed randomized controlled trials (RCTs) or quasi-RCTs were identified for inclusion in this systematic review.
The identified studies were either ongoing, had completed recruitment but were unpublished, or were suspended.

Conclusions:

There is a lack of RCT-based evidence to guide treatment guidelines for HIVAN.
Observational data suggest potential benefits of steroids and angiotensin-converting enzyme inhibitors (ACEi) on kidney function in HIVAN.
High-quality RCTs are urgently needed to establish evidence-based interventions for HIVAN management.