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Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...

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Related Experiment Video

Updated: Jun 19, 2026

Modified Laparoscopic Anatomic Hepatectomy: Two-Surgeon Technique Combined with the Simple Extracorporeal Pringle Maneuver
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Published on: June 16, 2023

Cardiopulmonary interventions to decrease blood loss and blood transfusion requirements for liver resection.

Kurinchi Selvan Gurusamy1, Jun Li, Dinesh Sharma

  • 1University Department of Surgery, Royal Free Hospital and University College School of Medicine, 9th Floor, Royal Free Hospital, Pond Street, London, UK, NW3 2QG.

The Cochrane Database of Systematic Reviews
|October 13, 2009
PubMed
Summary
This summary is machine-generated.

Cardiopulmonary interventions for liver resection show no significant benefit in peri-operative outcomes. While haemodilution may reduce blood transfusions, further research is needed due to high bias and small sample sizes in current studies.

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Application of Hemostatic Devices in Laparoscopic Hepatectomy
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Area of Science:

  • Hepatobiliary Surgery
  • Anesthesiology
  • Critical Care Medicine

Background:

  • Significant blood loss during liver resection impacts patient outcomes.
  • Minimizing blood loss and transfusion needs is crucial for liver surgery success.

Purpose of the Study:

  • To evaluate the efficacy and safety of cardiopulmonary interventions for reducing blood loss.
  • To assess the impact of these interventions on allogeneic blood transfusion requirements in liver resection patients.

Main Methods:

  • Systematic review of randomized clinical trials.
  • Searched major databases including Cochrane, MEDLINE, and EMBASE until November 2008.
  • Included trials comparing cardiopulmonary interventions (e.g., low CVP, autologous donation, haemodilution) regardless of resection type or vascular occlusion.

Main Results:

  • Nine trials with 587 patients were analyzed; all had a high risk of bias.
  • No significant differences in peri-operative mortality or morbidity were observed across interventions.
  • Haemodilution and controlled hypotension significantly reduced the need for allogeneic blood transfusions.

Conclusions:

  • Current cardiopulmonary interventions do not consistently improve peri-operative outcomes or long-term survival in liver resections.
  • Haemodilution shows potential for reducing transfusion needs, but evidence is limited by trial quality and size.
  • Further high-quality randomized trials are essential to confirm benefits and guide clinical practice for blood management in liver surgery.