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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jun 19, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
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Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

Cryotherapy for hepatocellular carcinoma.

Tahany Awad1, Kristian Thorlund, Christian Gluud

  • 1Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK-2100.

The Cochrane Database of Systematic Reviews
|October 13, 2009
PubMed
Summary
This summary is machine-generated.

Cryotherapy for liver cancer (hepatocellular carcinoma) lacks sufficient evidence for recommendation or refutation. More high-quality randomized clinical trials are needed to determine its effectiveness and safety.

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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
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Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

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Area of Science:

  • Hepatobiliary Medicine
  • Surgical Oncology
  • Interventional Radiology

Background:

  • Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy.
  • The efficacy and safety of cryotherapy for HCC treatment remain controversial.
  • Current evidence is insufficient to guide clinical practice.

Purpose of the Study:

  • To systematically review the existing literature on cryotherapy for hepatocellular carcinoma.
  • To evaluate the potential benefits and harms associated with cryotherapy in HCC treatment.
  • To identify the need for further research in this area.

Main Methods:

  • Comprehensive search of multiple electronic databases (Cochrane Hepato-Biliary Group, CENTRAL, MEDLINE, EMBASE, LILACS) and grey literature until June 2009.
  • Inclusion criteria focused on randomized clinical trials, quasi-randomized studies, and cohort studies comparing cryotherapy with control interventions.
  • Data extraction and analysis followed Cochrane Collaboration recommendations, assessing risk ratios and confidence intervals.

Main Results:

  • No randomized or quasi-randomized clinical trials were identified.
  • Two prospective and two retrospective cohort studies were found; only one was suitable for benefit assessment, comparing percutaneous cryotherapy with radiofrequency.
  • Adverse events were reported, but their true extent and nature were difficult to ascertain due to study limitations.

Conclusions:

  • There is currently no robust evidence to support or reject the use of cryotherapy for hepatocellular carcinoma.
  • High-quality randomized clinical trials with minimal bias are essential to establish the role of cryotherapy in HCC management.
  • Further research is crucial to define optimal treatment strategies for liver cancer.