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A facile approach to modify polyurethane surfaces for biomaterial applications.

Zhaoqiang Wu¹, Hong Chen, He Huang

¹State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China.

Macromolecular Bioscience

|October 13, 2009

Summary

We developed a simple method to modify polyurethane surfaces, significantly reducing protein adsorption. This technique works on complex shapes, offering a versatile solution for biomaterial applications.

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Area of Science:

Materials Science and Engineering
Biomaterials Science
Polymer Chemistry

Background:

Polyurethane (PU) is a widely used biomaterial, but its surface properties often require modification to improve biocompatibility.
Traditional surface modification methods like plasma treatment and photoinitiation face limitations, especially for complex geometries.
Reducing non-specific protein adsorption is crucial for enhancing the performance of biomedical devices and implants.

Purpose of the Study:

To introduce a facile and highly efficient surface modification method for polyurethane.
To demonstrate the incorporation of vinyl functionality onto the PU surface for subsequent polymerization.
To evaluate the impact of surface grafting on protein adsorption properties.

Main Methods:

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Surface functionalization of polyurethane using methacryloyl isothiocyanate (MI) to introduce double bonds.

Graft polymerization of monomers like N-isopropyl acrylamide (NIPAAm) and 2-hydroxyethyl methacrylate (HEMA) onto the vinyl-functionalized PU surface.

Analysis of protein adsorption on the modified and unmodified polyurethane surfaces.

Main Results:

Successful incorporation of vinyl groups onto the polyurethane surface via methacryloyl isothiocyanate.
Demonstrated successful graft polymerization of various monomers onto the functionalized PU surface.
Significantly reduced protein adsorption observed on all grafted surfaces compared to unmodified PU.

Conclusions:

The proposed method offers an efficient approach for surface modification of polyurethane.
Grafting polymers onto the modified PU surface effectively reduces protein adsorption.
This technique is versatile and applicable to complex PU shapes, overcoming limitations of conventional methods.