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Updated: Jun 19, 2026

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

Published on: October 17, 2016

Biodegradable polymeric microcarriers with controllable porous structure for tissue engineering.

Xudong Shi¹, Lei Sun, Jian Jiang

¹The CAS Key Laboratory of Engineering Plastics, Joint Laboratory of Polymer Science and Materials, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, PR China.

Macromolecular Bioscience

|October 13, 2009

Summary

This summary is machine-generated.

Biodegradable poly(DL-lactide) microspheres were fabricated for tissue engineering. These porous microspheres show potential as cell delivery carriers, supporting MG-63 cell attachment and spreading.

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Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Fabrication of Extracellular Matrix-derived Foams and Microcarriers as Tissue-specific Cell Culture and Delivery Platforms

Published on: April 11, 2017

Area of Science:

Biomaterials Science
Tissue Engineering
Polymer Chemistry

Background:

Biodegradable polymers are crucial for developing effective cell delivery systems in tissue engineering.
Porous microspheres offer a promising scaffold for cell cultivation and tissue regeneration.
Poly(DL-lactide) (PLA) is a well-established biodegradable polymer with potential for biomedical applications.

Purpose of the Study:

To fabricate porous poly(DL-lactide) (PLA) microspheres using a modified double emulsion solvent evaporation method.
To investigate the influence of fabrication parameters on the porous structure of PLA microspheres.
To evaluate the potential of these microspheres as cell delivery carriers for tissue engineering.

Main Methods:

Fabrication of porous PLA microspheres via a modified double emulsion solvent evaporation technique.
Systematic variation of fabrication parameters including stirring speed, polymer concentration, solvent type, and post-hydrolysis treatment.
Assessment of microsphere morphology and porous structure.
Evaluation of MG-63 cell attachment, spreading, and viability on the fabricated microspheres.

Main Results:

Successful fabrication of porous poly(DL-lactide) microspheres with controllable structures.
Demonstrated influence of key fabrication parameters on microsphere porosity and morphology.
Observed good attachment and active spreading of MG-63 cells on the surface of the PLA microspheres.
Indicated successful cell integration with the porous microsphere scaffold.

Conclusions:

Porous PLA microspheres can be effectively fabricated using a modified double emulsion solvent evaporation method.
Fabrication parameters significantly influence the resulting porous structure of the microspheres.
The developed PLA microspheres serve as a promising scaffold for cell cultivation and demonstrate potential as cell delivery carriers in tissue engineering applications.