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Related Concept Videos

Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...

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Folding and Characterization of a Bio-responsive Robot from DNA Origami
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A nanostructure made of a bacterial noncoding RNA.

Bastien Cayrol1, Claude Nogues, Alexandre Dawid

  • 1Institut Curie, Research Division, CNRS UMR 168, Paris 75248, France.

Journal of the American Chemical Society
|October 14, 2009
PubMed
Summary

Escherichia coli DsrA RNA self-assembles into nanostructures via antisense interactions. These structures transition into stable helical filaments, suggesting implications for DsrA

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Area of Science:

  • Molecular Biology
  • RNA Nanostructures
  • Biophysics

Background:

  • Natural RNAs rarely form extended nanostructures, unlike synthetic nucleic acids.
  • The formation of complex RNA nanostructures is a significant challenge in molecular biology.

Purpose of the Study:

  • To investigate the self-assembly capabilities of natural noncoding RNAs.
  • To characterize the nanostructure formation of Escherichia coli DsrA RNA.

Main Methods:

  • Atomic Force Microscopy (AFM) for structural visualization.
  • Fluorescence microscopy to observe nanostructure dynamics.
  • Molecular modeling to understand structural transitions.

Main Results:

  • DsrA RNA self-assembles into a hierarchy of nanostructures through antisense interactions.
  • These nanostructures readily convert into stable, large helical filaments (>100 nm).
  • DsrA filaments exhibit remarkable resistance to heat and urea denaturation.

Conclusions:

  • DsrA RNA demonstrates a unique ability to form hierarchical nanostructures and stable filaments.
  • The structural switch is driven by the release of torsional constraints.
  • Findings suggest novel regulatory roles for DsrA RNA based on its structural plasticity.