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Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants


Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
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CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Peptic Ulcer Disease IV: Management

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Updated: Jun 19, 2026

Testing Nicotine Tolerance in Aphids Using an Artificial Diet Experiment
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Published on: May 14, 2008

Nicotine replacement therapy as a treatment for complex aphthosis.

Samantha C Hill1, Anastasios Stavrakoglou, Ian R Coutts

  • 1The Tudor Centre for Sexual Health, The Hillingdon Hospital, Uxbridge, Middlesex, UK. dr_shill@yahoo.co.uk

The Journal of Dermatological Treatment
|October 14, 2009
PubMed
Summary

Complex aphthosis, characterized by recurrent oral and genital ulcers, can be effectively treated with nicotine therapy. This nicotine lozenge treatment proved successful for a patient who developed aphthosis after quitting smoking.

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Area of Science:

  • Oral medicine
  • Dermatology
  • Immunology

Background:

  • Complex aphthosis involves recurrent oral and genital aphthous ulceration without systemic disease, with an unknown cause.
  • Recurrent aphthous stomatitis (RAS) is less prevalent in smokers, suggesting a potential role for nicotine.

Observation:

  • A patient developed complex aphthosis shortly after cessation of smoking.
  • Conventional treatments for aphthosis were ineffective in this patient.

Findings:

  • Nicotine lozenges successfully resolved the patient's aphthous ulceration.
  • This suggests nicotine may influence the course of aphthous ulceration.

Implications:

  • Nicotine therapy may be a viable treatment option for complex aphthosis, especially in ex-smokers.
  • Further research into nicotine's mechanisms in aphthosis is warranted.
  • Consider nicotine therapy when standard treatments fail for recurrent aphthous stomatitis.