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Updated: Jun 19, 2026

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

Published on: September 7, 2018

Canine platelet transfusions.

Mary Beth Callan¹, Elizabeth H Appleman, Bruce S Sachais

¹Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA. callan@vet.upenn.edu

Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001)

|October 14, 2009

Summary

This summary is machine-generated.

Fresh platelet concentrates are best for severe bleeding. While cryopreservation and lyophilization offer immediate availability and long-term storage, they reduce platelet recovery and function, though they can still be life-saving.

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Area of Science:

Hematology
Transfusion Medicine
Veterinary Hematology

Background:

Platelet concentrates (PCs) are vital for managing severe thrombocytopenia.
Current storage involves 22°C with agitation for up to 5 days.
Chilling and galactosylation have not improved platelet survival.

Purpose of the Study:

To review platelet storage options.
To examine guidelines for platelet administration.
To identify adverse events in platelet transfusions.

Main Methods:

Literature review of original research and scientific reviews.
Analysis of human and canine platelet transfusion data.
Evaluation of storage, administration, and adverse events.

Main Results:

Human platelet cryopreservation in DMSO is largely experimental.
Pre-storage leukoreduction reduces but doesn't eliminate transfusion reactions.
Canine plateletpheresis yields higher platelet counts than whole blood.
Canine platelet cryopreservation offers immediate availability but reduced in vivo recovery.
Lyophilized canine platelets are useful for active bleeding control.

Conclusions:

Fresh platelet concentrates are the preferred treatment for bleeding due to thrombocytopenia or thrombopathia.
Canine platelet cryopreservation and lyophilization provide immediate access and long-term storage.
These methods compromise in vivo recovery and function but can be life-saving.