Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

What is Cancer?

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.

Communications biology·2024

Same author

Multimodal assessment improves neuroprognosis performance in clinically unresponsive critical-care patients with brain injury.

Nature medicine·2024

Same author

PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study.

BMC neurology·2022

Same author

Outbreak Investigation of Influenza in Pajaru VDC of Jajarkot District of Nepal.

Journal of Nepal Health Research Council·2017

Same author

Effects of type II collagen epitope carbamylation and citrullination in human leucocyte antigen (HLA)-DR4(+) monozygotic twins discordant for rheumatoid arthritis.

Clinical and experimental immunology·2016

Same author

Osteoanabolic therapy: a valid option to reduce refracture risk after vertebral augmentation procedures?

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016

Same journal

Glycolysis and neutrophil extracellular traps in atherosclerosis: Mechanisms, association, and therapeutic strategies.

International journal of immunopathology and pharmacology·2026

Same journal

Development of RNase P ribozyme-based therapy against oral herpesvirus infections by HSV-1 and KSHV.

International journal of immunopathology and pharmacology·2026

Same journal

Liposomal nanotherapeutics for cancer treatment: Targeted delivery and immunotherapy.

International journal of immunopathology and pharmacology·2026

Same journal

Apoptosis enhancement in MCF-7 cells: Synergistic effects of doxorubicin and the novel sulfonamide Zm-093.

International journal of immunopathology and pharmacology·2026

Same journal

Primary epithelioid angiosarcoma of thyroid: A case report and review of literature.

International journal of immunopathology and pharmacology·2026

Same journal

Retraction: Adipose stem cells' antagonism in glycosylation of D-galactose-induced skin aging of nude mice and its skin recovery function.

International journal of immunopathology and pharmacology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic sclerosis and cancer.

B Marasini¹, L Conciato, L Belloli

¹Rheumatology Unit, IRCCS Istituto Clinico Humanitas, University of Milan, Milan, Italy. bianca.marasini@humanitas.it

International Journal of Immunopathology and Pharmacology

|October 14, 2009

Summary

This summary is machine-generated.

Systemic sclerosis (SSc) and cancer, particularly lung and breast malignancies, may be linked, but the causal relationship remains controversial. Localized scleroderma (morphoea) is generally not associated with cancer, except in specific cases.

More Related Videos

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

Rheumatology and Oncology
Autoimmune Diseases
Cancer Research

Background:

Systemic sclerosis (SSc) and cancer coexist, with lung and breast malignancies being most common.
Localized scleroderma (morphoea) is typically not associated with cancer, except for squamous cell carcinoma in pansclerotic morphoea with skin ulcers.

Discussion:

Mechanisms linking SSc and cancer are unknown, but may involve immune response, genetics, environment, or therapies.
Sclerosis may promote cancer, and radiotherapy, especially for breast cancer, can trigger or worsen SSc and morphoea.
SSc is considered a relative contraindication for breast radiotherapy due to potential adverse effects.

Key Insights:

The association between SSc and various cancers suggests diverse underlying mechanisms.
Radiotherapy for breast cancer poses risks for patients with SSc or morphoea.
A definitive causal link between SSc and cancer is yet to be established.

Outlook:

Further research into the modalities of SSc-cancer associations is crucial.
Understanding these links may reveal underlying biological mechanisms.
Identifying patients at risk for both conditions is a key future goal.