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Platelet activation and endogenous thrombin potential in pre-eclampsia
1Department of Haematology, Barts and the London NHS Trust, London, UK. marion.macey@bartsandthelondon.nhs.uk
Thrombosis Research
|October 14, 2009
Summary
Pre-eclampsia involves platelet and coagulation activation. This study found significantly higher levels of activated platelets and platelet aggregates in women with pre-eclampsia compared to pregnant controls.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Pathophysiology
Background:
- Platelets and the coagulation system are implicated in pre-eclampsia pathogenesis.
- Previous research suggests a potential role for these systems in the condition.
Purpose of the Study:
- To investigate elevated platelet and coagulation activation markers in pre-eclampsia.
- To compare activation markers between pre-eclamptic, normotensive pregnant, and non-pregnant women.
Main Methods:
- A case-control study design was employed.
- Flow cytometry assessed activated platelets, platelet-monocyte/neutrophil aggregates, and platelet microparticles.
- Calibrated Automated Thrombogram system measured thrombin generation capacity markers: endogenous thrombin potential (ETP), peak height, lag time, and time to peak.
Main Results:
- Women with pre-eclampsia showed significantly higher percentages of CD62P+ platelets, CD62P+ platelet microparticles, and platelet-monocyte aggregates compared to pregnant controls.
- Both pregnant groups exhibited significantly higher ETP and peak height than non-pregnant women.
- Women with pre-eclampsia had significantly higher ETP and peak height than normotensive pregnant controls.
Conclusions:
- This study provides comprehensive laboratory evidence of both platelet and coagulation activation in pre-eclampsia.
- Findings support the involvement of these systems in the pathophysiology of pre-eclampsia.
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