Related Experiment Video
Updated: Jun 19, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
Published on: September 28, 2012
Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response
Vanessa Dehennaut1, Dominique Leprince
1CNRS-UMR 8161, Institut de Biologie de Lille, Université de Lille-Nord de France, Institut Pasteur de Lille, IFR 142, 1, rue Calmette, BP447, 59017, Lille Cedex, France. vanessa.dehennaut@ibl.fr
Abstract:
HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C(2)H(2) zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.
More Related Videos
12:19Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
Published on: November 10, 2016
09:14Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
Published on: January 14, 2016
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle
Hedgehog Signaling Pathway
Heterochromatin
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...