Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
Amplifying Signals via Second Messengers01:15

Amplifying Signals via Second Messengers

Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief.

bioRxiv : the preprint server for biology·2026
Same author

Time to spare: 1-Minute vs 2-minute intercostal nerve cryoablation during minimally invasive repair of pectus excavatum.

Journal of pediatric surgery·2026
Same author

Neuropilin-1 mediates nerve growth factor signaling of oral cancer pain.

Pain·2026
Same author

Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome.

Gut·2026
Same author

Neural Crest-Derived Stem Cell Secretomes and Extracellular Vesicles Disrupt Glioblastoma through Dual-Pathway Inflammatory Rebalancing.

Stem cell reviews and reports·2026
Same author

PurePectus bars: Initial surgical experience and early outcomes in 111 patients.

Journal of pediatric surgery·2026

Related Experiment Video

Updated: Jun 19, 2026

Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells
11:31

Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells

Published on: May 12, 2023

Endosomes: a legitimate platform for the signaling train.

Jane E Murphy1, Benjamin E Padilla, Burcu Hasdemir

  • 1Department of Surgery, University of California, San Francisco, CA 94143, USA.

Proceedings of the National Academy of Sciences of the United States of America
|October 14, 2009
PubMed
Summary

The endosomal system is crucial for cell signaling, not just degradation. Endosomal receptor signaling transmits distinct physiological responses and offers novel therapeutic targets.

More Related Videos

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells
11:31

Image-Based Methods to Study Membrane Trafficking Events in Stomatal Lineage Cells

Published on: May 12, 2023

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
12:24

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

Published on: September 29, 2016

Area of Science:

  • Cell Biology
  • Molecular Signaling
  • Drug Discovery

Background:

  • The endosomal system was traditionally viewed as solely for receptor degradation or recycling.
  • Emerging evidence highlights the endosome as a critical platform for signal transduction.
  • Receptor signaling initiated at the plasma membrane can continue within endosomes, leading to unique cellular outcomes.

Purpose of the Study:

  • To elucidate the role of the endosomal system in signal transduction.
  • To explore the distinct signaling events originating from endosomes.
  • To identify endosomal signaling pathways as potential therapeutic targets.

Main Methods:

  • Investigated receptor localization and signaling component recruitment to endosomes.
  • Analyzed distinct physiological responses mediated by endosomal signaling.
  • Examined regulatory mechanisms controlling endosomal receptor signaling.

Main Results:

  • Activated receptors accumulate in endosomes, initiating unique signaling cascades.
  • Endosomal signaling regulates fundamental processes like growth, differentiation, and survival in metazoans and plants.
  • Signaling from endosomes differs from plasma membrane signaling, eliciting distinct cellular responses.

Conclusions:

  • The endosomal system is an essential site for signal transduction with significant physiological roles.
  • Targeting endosomal-specific signaling pathways or drug delivery to endosomes may offer novel therapeutic strategies for various diseases.