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Synthesis and pharmacological properties of nebivolol, a new antihypertensive compound
G Van Lommen1, M De Bruyn, M Schroven
1Janssen Research Foundation, Synthetic Department, Beerse, Belgium.
Journal De Pharmacie De Belgique
|November 1, 1990
Abstract:
The synthesis of alpha,alpha' (iminobis(methylene]-bis-(3,4-dihydro-2H-1benzopyran-2-metha nol) derivatives and the stereochemistry and pharmacological profile of this new class of antihypertensive compounds are described. Finally, the selection and pharmacological profile of the preferred compound of this series, nebivolol and its enantiomers, is discussed.