Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.7K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.1K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoplasmic reticulum-targeted gold nanorod for chemo-photothermal therapy induces ER stress-mediated autophagy and apoptosis in cancer cells.

Journal of materials chemistry. B·2026
Same author

Rationally designed mitochondria-impairing small molecule-enabled chemo-phototherapy to potentiate apoptosis and autophagy in cancer cells.

Journal of materials chemistry. B·2026
Same author

Activating a B cell immune response regresses immunologically cold tumours.

Nature nanotechnology·2026
Same author

Soft matrix: probing local mechanical properties in amorphous solids.

Soft matter·2026
Same author

Thermal fluctuation driven structural relaxation in undeformed glasses: Unraveling the evolution of mechanical stability.

Physical review. E·2026
Same author

Graphene-Oxide-Mediated Photothermal Ring-Closing Metathesis: A Gateway for Organelle Imaging Probes.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Feb 12, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

998

Targeting oncogenic signaling pathways by exploiting nanotechnology.

Sudipta Basu1, Padmaparna Chaudhuri, Shiladitya Sengupta

  • 1Harvard-MIT Division of Health Science and Technology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Cell Cycle (Georgetown, Tex.)
|October 14, 2009
PubMed
Summary

Revolutionary cancer chemotherapy combines cellular signaling pathway insights with nanotechnology. This approach engineers targeted nanoparticles to deliver chemotherapy drugs, improving treatment efficacy and overcoming drug resistance for better patient outcomes.

More Related Videos

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.8K

Related Experiment Videos

Last Updated: Feb 12, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

998
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

8.0K
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.8K

Area of Science:

  • Oncology and Nanomedicine
  • Cancer Signaling Pathways
  • Nanotechnology Applications in Drug Delivery

Background:

  • Cancer chemotherapy faces challenges with drug resistance and limited efficacy.
  • Cellular signaling pathways are crucial in cancer development, progression, and treatment resistance.
  • Nanotechnology offers novel platforms for enhancing anticancer agent delivery and targeting.

Purpose of the Study:

  • To explore the integration of cancer signaling pathway knowledge and nanotechnology.
  • To review the engineering of nanoparticles for targeted cancer therapy.
  • To discuss the potential of nanomedicine in overcoming chemotherapy limitations.

Main Methods:

  • Review of current research on cancer signaling pathways.
  • Analysis of nanotechnology-based drug delivery systems.
  • Discussion of nanoparticle design for targeting specific cancer pathways.

Main Results:

  • Identification of key signaling pathways as potential drug targets.
  • Development of customizable nanoparticles for drug payload delivery.
  • Demonstration of nanotechnology's potential to improve therapeutic index.

Conclusions:

  • Integrating nanotechnology with signaling pathway knowledge can revolutionize cancer chemotherapy.
  • Targeted nanoparticles offer a promising strategy to enhance drug efficacy and overcome resistance.
  • This interdisciplinary approach holds significant potential for future cancer treatment.