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Related Experiment Video

Updated: Jun 19, 2026

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
06:50

Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb

Published on: December 2, 2017

Multispectral tissue characterization with time-resolved detection of diffusely scattered white light.

S Andersson-Engels, R Berg, A Persson

    Optics Letters
    |October 14, 2009
    PubMed
    Summary

    This study introduces a new noninvasive method to measure tissue optical properties across visible and near-infrared light spectrums. It utilizes time-resolved detection of multicolor scattered light for comprehensive optical analysis.

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    Last Updated: Jun 19, 2026

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    Simultaneous Evaluation of Cerebral Hemodynamics and Light Scattering Properties of the In Vivo Rat Brain Using Multispectral Diffuse Reflectance Imaging

    Published on: May 7, 2017

    Area of Science:

    • Biophotonics
    • Optical Physics
    • Medical Imaging

    Background:

    • Accurate measurement of tissue optical properties is crucial for various biomedical applications.
    • Existing techniques may lack simultaneous multi-wavelength capabilities or invasiveness.

    Purpose of the Study:

    • To present a novel technique for noninvasive measurement of tissue optical properties.
    • To achieve simultaneous measurement across all visible and near-infrared wavelengths.

    Main Methods:

    • Utilizes time-resolved detection of multicolor diffusely scattered light.
    • Generates short pulses of white light via self-phase modulation using a high-power laser and water.
    • Employs spectral dispersion (polychromator) and temporal dispersion (streak tube) with a 2D CCD camera for detection.

    Main Results:

    • The technique enables simultaneous measurement of tissue optical properties.
    • Covers the entire visible and near-infrared spectrum.
    • Provides both time and wavelength resolution.

    Conclusions:

    • The developed technique offers a comprehensive approach for noninvasive optical property assessment.
    • Potential applications in diagnostics, imaging, and therapeutic monitoring.