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Related Experiment Videos

Non-synaptic chemical neurotransmission.

E Ramon-Moliner

    Experientia
    |October 15, 1977
    PubMed
    Summary

    Olfactory bulb images showing gemmulofugal polarity are artifacts from sectioning. Internal granule cells lack these synapses, suggesting neurotransmitters act on non-synaptic membranes.

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    The reciprocal synapses of the olfactory bulb: questioning the evidence.

    Brain research·1977

    Area of Science:

    • Neuroscience
    • Cell Biology

    Background:

    • The olfactory bulb's external plexiform layer (EPL) exhibits complex synaptic organization.
    • Understanding synaptic polarity is crucial for interpreting neural circuit function.

    Purpose of the Study:

    • To re-evaluate the apparent gemmulofugal polarity observed in the olfactory bulb's EPL.
    • To determine the true synaptic connections of internal granule cells.

    Main Methods:

    • Analysis of synaptic structures within the olfactory bulb EPL.
    • Microscopic examination of sectioned neural tissue.

    Main Results:

    • Observed gemmulofugal polarity in EPL images is an artifact of sectioning planes.
    • Gemmulopetal synapses with postsynaptic vesicles were misinterpreted.
    • Internal granule cells do not possess true gemmulofugal synapses.

    Conclusions:

    • Apparent gemmulofugal synapses in the olfactory bulb EPL are sectioning artifacts.
    • Neurotransmitters from internal granule cell vesicles likely act on non-synaptic membranes.

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