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Related Experiment Video

Updated: Jun 19, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Quetiapine: Relatively safe in overdose?

Surendra K Mattoo¹, Ruchita Shah, R Rajagopal

¹Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India.

Indian Journal of Psychiatry

|October 14, 2009

Summary

Quetiapine is a relatively safer antipsychotic in overdose cases. A patient who took 1400 mg experienced mild symptoms and recovered, supporting its use in suicidal patients.

Keywords:

Overdose deliberate self harm psychosis quetiapine schizophrenia

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Area of Science:

Pharmacology
Toxicology
Psychiatry

Background:

Quetiapine is an atypical antipsychotic used for schizophrenia and bipolar disorder.
Antipsychotic overdose cases present a significant clinical challenge.
Previous reports suggest quetiapine may have a favorable safety profile in overdose compared to other agents.

Purpose of the Study:

To report a case of quetiapine overdose and its management.
To evaluate the safety of quetiapine in a significant overdose scenario.
To support the existing literature on quetiapine's relative safety in overdose.

Main Methods:

Case report of a patient with paranoid schizophrenia attempting suicide with quetiapine.
Administration of 1400 mg of quetiapine.
Management included gastric lavage, intravenous lorazepam for agitation, and emergency observation.
Subsequent treatment with electroconvulsive therapy (ECT), quetiapine, and risperidone.

Main Results:

The patient presented with drowsiness and supraventricular tachycardia (167/minute).
Electrocardiogram (ECG) showed minimal ST depression in anterior leads (V1-V6).
Other physiological parameters remained normal.
The patient was discharged after 14 hours of observation and later managed successfully with combined therapies.

Conclusions:

This case supports the literature suggesting quetiapine is relatively safer in overdose.
Quetiapine may be a preferable option in patients with suicidal ideation and risk of medication overdose.
Prompt management and continued treatment were effective in patient recovery.