Related Experiment Video
Updated: Jun 19, 2026

Isolation, Behavioral Identification, and Pathogenicity Assessment of Entomopathogenic Fungi from a Forest Wood Borer
Published on: September 29, 2023
[The characteristics of the insidious pathogen doctrine of Wu You-xing]
1China Institute for History of Medicine and Medical Literature, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Abstract:
The concept of insidious pathogen originated in Nei jing ( Yellow Emperors Inner Classic). Wu You-xing put forward the concept of an epidemic noxious factor on the basis of predecessors' work and gave a new connotation to insidious pathogen in the late Ming dynasty. Wu You-xing held that the cold pathogen was invisible while the epidemic noxious factor was tangible and concrete; the hidden location of the pathogen is Mo yuan, and the pathogen concealed in Mo yuan is the elementary process of epidemic disease, not hidden and not attacking. It can be treated by Da yuan yin.
Insights
The concept of insidious pathogens, originating in the Yellow Emperors Inner Classic, was redefined by Wu You-xing in the late Ming dynasty. He described epidemic noxious factors as tangible, concrete entities hidden in Mo yuan, treatable with Da yuan yin.
Area of Science:
- Traditional Chinese Medicine
- History of Medicine
- Pathology
Context:
- The concept of insidious pathogens traces back to the Nei jing (Yellow Emperors Inner Classic).
- Wu You-xing expanded upon these ideas in the late Ming dynasty, introducing the concept of epidemic noxious factors.
- This work builds upon foundational principles of ancient Chinese medical texts.
Purpose:
- To explore the historical evolution and conceptualization of insidious pathogens in traditional Chinese medicine.
- To analyze Wu You-xing's specific contributions to understanding epidemic noxious factors.
- To highlight the theoretical framework and proposed treatments for epidemic diseases in historical Chinese medical literature.
Summary:
- Wu You-xing proposed that epidemic noxious factors are tangible and concrete, contrasting with invisible cold pathogens.
- He identified Mo yuan as the hidden location of these pathogens, representing the initial stage of disease.
- The text suggests that Da yuan yin is an effective treatment for conditions involving pathogens concealed in Mo yuan.
Impact:
- Provides historical context for understanding epidemic disease concepts in Traditional Chinese Medicine.
- Highlights the theoretical underpinnings of ancient Chinese medical pathology and treatment strategies.
- Offers insights into the development of medical thought during the late Ming dynasty.
Related Concept Videos
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Plague
Colonisation of Pathogens
Infectious Diseases and Their Occurrence
Stages of Infection
Reservoir of Infection
