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Updated: Jun 19, 2026

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
[Diagnostic capacities of optical coherent tomography in central serous chorioretinopathy]
Abstract:
Optic coherent tomography (OCT) was used to examine 123 patients with central serous chorioretinopathy (CSC) first detected in one eye; spectral OCT (SOCT) was also performed in 36 patients. According to SOCT data; CSC was characterized by preservation of the external borderline membrane and a drastic optic density reduction, and no coupling of the external and internal segments of photoreceptors; when the disease was prolonged, there were pronounced changes in external segments of photoreceptors--a notched contour, fragmentation, etc. OCT revealed pigment epithelium alterations (detachment or deformity) in 40.8% of cases whereas SOCT in all cases, including changes in small sizes, located at the periphery of the macular area. A coincidence of PE alterations was established from the data of SOCT and the points of fluorescein leakage on the angiograms. It is suggested that SOCT may be used to determine the localization of liquid filtration points in patients having contraindications to fluorescence angiography of the fundus of the eye.
