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Updated: Jun 19, 2026

Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
Published on: April 14, 2023
[Role of tropomyosin isoforms in diversification of actin filaments functions]
1Zakład Biochemii i Biologii Komórki, Instytut Biologii Eksperymantalnej, Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Bydgoszcz. moraczjo@ukw.edu.pl
Abstract:
Actin interactions with myosin as well as dynamic polymerization and depolymerization of actin filaments underlie various forms of cellular motility. Both mechanisms are under control of regulatory proteins, among which tropomyosins take a central position. Tropomyosin isoforms can be tissue-specific or constitutive, expressed in different cell types. Tropomyosin expression pattern depends on the cell type and developmental stage. Several tropomyosin isoforms can simultanously co-exist in a single cell, and they are subjected to sorting to different cellular compartments. Due to specific localization, tropomyosins determine interactions of the filaments with actin binding proteins, and ascertain various filaments functions.
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