Related Experiment Video
Updated: Jun 19, 2026
Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
A randomized, controlled clinical trial of one-step self-etching adhesive systems in non-carious cervical lesions
Zeyuan Zhou1, Shuxiang Yu, Yong Jiang
1Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, 145 West Changle Road, Xi'an, Shaanxi 710032, PR China.
Purpose:
To evaluate the clinical effectiveness of two different one-step self-etching adhesives.
Methods:
Two single-step self-etching adhesive systems, Clearfil Tri-S Bond and G-Bond, were evaluated. As a control, a two-step self-etching adhesive system, Clearfil SE Bond, was used. The teeth to be restored were randomly assigned. The resin composite used to restore the teeth was Clearfil AP-X. The three adhesive systems were evaluated by Modified USPHS at baseline, 3 months, 6 months, and 12 months. The evaluation consisted of retention rate, color match, marginal discoloration (interfacial staining), marginal adaptation (integrity), wear, post-operative sensitivity, caries recurrence, and other failures. Changes over time and across groups were evaluated statistically using generalized estimating equations.
Results:
During the 12-month study period, no statistical differences were observed among the three groups (P > 0.05) in retention rate, color match, marginal discoloration (interfacial staining), marginal adaptation (integrity). No wear, post-operative sensitivity, caries recurrence, or other failures were detected in any groups. The two one-step self-etching adhesives tested showed good clinical performance at the end of 12 months.