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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Related Experiment Video

Updated: Jun 19, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

Chronic constipation: overview and challenges.

I J Cook1, N J Talley, M A Benninga

  • 1University of New South Wales, Department of Gastroenterology, St George Hospital, Sydney, NSW, Australia. i.cook@unsw.edu.au

Neurogastroenterology and Motility
|October 15, 2009
PubMed
Summary
This summary is machine-generated.

Constipation pathophysiology is poorly understood, limiting treatment options. This research explores knowledge gaps and suggests future research directions for better constipation therapies.

Related Experiment Videos

Last Updated: Jun 19, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

Area of Science:

  • Gastroenterology
  • Physiology

Background:

  • Constipation is a prevalent condition with significant healthcare costs.
  • Current understanding of constipation pathophysiology is limited.
  • Existing therapies for constipation demonstrate suboptimal efficacy.

Purpose of the Study:

  • To critically evaluate the reasons behind the deficient understanding of constipation pathophysiology.
  • To propose targeted research avenues to address current knowledge gaps.
  • To improve the development of effective constipation treatments.

Main Methods:

  • Literature review and critical analysis of existing research on constipation.
  • Identification of key areas lacking scientific investigation.
  • Synthesis of expert opinions on future research priorities.

Main Results:

  • Identified significant deficiencies in basic science and clinical research regarding constipation.
  • Highlighted the need for advanced research methodologies to elucidate complex pathophysiological mechanisms.
  • Outlined specific research questions and experimental approaches.

Conclusions:

  • A fundamental gap in understanding constipation's underlying mechanisms hinders therapeutic progress.
  • Future research should focus on molecular, cellular, and systemic levels of investigation.
  • Addressing these research deficiencies is crucial for developing novel and effective constipation treatments.