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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
12:40

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Helminths and malignancy.

B J Vennervald1, K Polman

  • 1DBL-Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark. bjv@life.ku.dk

Parasite Immunology
|October 15, 2009
PubMed
Summary
This summary is machine-generated.

Helminth infections, particularly Schistosoma haematobium and liver flukes, are preventable causes of cancer linked to chronic inflammation and DNA damage. Sustainable control and health education are crucial in endemic areas to reduce cancer risk.

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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
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Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
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Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

Area of Science:

  • Parasitology
  • Oncology
  • Immunology

Background:

  • Chronic infections contribute significantly to the global cancer burden.
  • Helminth infections, though a smaller proportion, are important due to widespread exposure.
  • Chronic inflammation is a key mechanism in helminth-associated carcinogenesis.

Purpose of the Study:

  • To explore the complex mechanisms of helminth-induced carcinogenesis.
  • To highlight the role of chronic inflammation in cancer development.
  • To identify specific helminth infections classified as human carcinogens.

Main Methods:

  • Review of existing literature on helminth infections and cancer.
  • Analysis of the immunopathological processes involved in inflammation.
  • Classification of carcinogenic helminths based on human evidence.

Main Results:

  • Helminth infections can lead to chronic inflammation, DNA damage via free radicals, and tissue damage promoting cell proliferation.
  • Schistosoma haematobium (bladder cancer), Clonorchis sinensis, and Opisthorchis viverrini (cholangiocarcinoma) are Group 1 carcinogens.
  • Reduced infection levels decrease cancer risk.

Conclusions:

  • Helminth infections are a preventable cause of cancer.
  • Sustainable helminth control programs and health education are vital in endemic regions.
  • Targeting food-borne liver fluke infections is particularly important.