Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 19, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model
09:01

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Published on: May 5, 2018

Pancreatic islet transplantation.

Maria Lúcia Corrêa-Giannella1, Alexandre S Raposo do Amaral

  • 1Laboratory of Cellular and Molecular Endocrinology (LIM25) - University of São Paulo Medical School, São Paulo, Brazil. malugia@lim25.fm.usp.br.

Diabetology & Metabolic Syndrome
|October 15, 2009
PubMed
Summary

Pancreatic islet transplantation offers a potential solution for type 1 diabetes by restoring insulin secretion. However, challenges remain in long-term graft survival and achieving insulin independence for all patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyperinsulinemic hypoglycemia due to pathogenic INSR variants: metabolic signature, phenotypic overlap, and semidominant inheritance.

Frontiers in endocrinology·2026
Same author

Machine learning-enhanced plasma proteomics discriminates pancreatic cancer-associated diabetes from type 2 diabetes mellitus.

Journal of proteomics·2026
Same author

Cross-talk between lipopolysaccharide tolerance and AGEs in the regulation of macrophage inflammation and cholesterol efflux.

Frontiers in immunology·2026
Same author

The impact of <i>APOE</i> ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effects.

Alzheimer's & dementia (Amsterdam, Netherlands)·2025
Same author

Gene Expression in Urinary Sediment Cells as an Indicator of the Contribution of Plasma Lipids to Diabetic Kidney Disease.

Journal of diabetes research·2025
Same author

Aerobic Exercise Training Protects Against Insulin Resistance, Despite Low-Sodium Diet-Induced Increased Inflammation and Visceral Adiposity.

International journal of molecular sciences·2024

Area of Science:

  • Endocrinology
  • Transplantation Immunology
  • Regenerative Medicine

Background:

  • Current insulin therapies fail to replicate physiological insulin secretion patterns.
  • Pancreas and islet transplantation are the only methods to restore endogenous insulin production in type 1 diabetes.
  • Pancreatic islet transplantation is a viable alternative due to the small endocrine portion of the pancreas.

Purpose of the Study:

  • To evaluate the efficacy and limitations of current human islet transplantation protocols.
  • To identify key challenges hindering long-term graft function and patient insulin independence.
  • To highlight strategies for optimizing islet transplantation outcomes.

Main Methods:

  • Review of International Islet Transplant Registry data (1983-2000).

More Related Videos

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Intraportal Transplantation of Pancreatic Islets in Mouse Model
09:01

Intraportal Transplantation of Pancreatic Islets in Mouse Model

Published on: May 5, 2018

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
11:57

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice

Published on: July 23, 2017

  • Analysis of outcomes following the Edmonton Protocol (steroid-free immunosuppression, increased islet mass).
  • Assessment of 5-year follow-up data in 65 patients.

    • Main Results:

    • The Edmonton Protocol improved 1-year outcomes compared to earlier methods.
    • Significant improvement in glycemic instability was observed in a portion of patients.
    • Only 7.5% of patients achieved insulin independence at 5 years, indicating functional graft loss.

    Conclusions:

    • Human islet transplantation can reduce severe hypoglycemia and improve glycemic control for 4-5 years in selected patients.
    • Limitations persist, including cell loss, graft rejection, and immunosuppression side effects.
    • The current procedure is not universally suitable for all type 1 diabetes patients.