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Related Experiment Videos

Peptide opioids and morphine effects on inflammatory process.

A Mazzone1, G Ricevuti, D Pasotti

  • 1Department of Internal Medicine and Therapeutics, University of Pavia, IRCCS San Matteo Hospital, Italy.

Inflammation
|December 1, 1990
PubMed
Summary
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Morphine inhibits human granulocyte aggregation and secretion of ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4). This effect is naloxone-sensitive, suggesting opioid receptor involvement in granulocyte activation.

Area of Science:

  • Immunology
  • Pharmacology

Background:

  • Opioids are known for pain management.
  • Their effects on immune cells like granulocytes are less understood.

Purpose of the Study:

  • To investigate the impact of morphine and opioid peptides on human granulocyte function.
  • To elucidate the role of opioid receptors in granulocyte activation.

Main Methods:

  • Assessing human granulocyte aggregation.
  • Measuring secretion of adenosine triphosphate (ATP), thromboxane B2 (TxB2), and leukotriene B4 (LTB4).
  • Evaluating the effect of naloxone and specific opioid peptides.

Main Results:

  • Morphine significantly inhibited granulocyte aggregation and ATP, TxB2, and LTB4 secretion.

Related Experiment Videos

  • Opioid peptides did not mimic morphine's inhibitory effects; dynorphin 1-9 stimulated secretion.
  • Naloxone reversed morphine's inhibition of aggregation and ATP secretion.
  • Morphine impaired CD11b-CD18 complex expression in a naloxone-sensitive manner.

    • Conclusions:

    • Morphine exerts inhibitory effects on human granulocyte activation.
    • These effects are mediated through naloxone-sensitive opioid receptors.
    • Morphine's modulation of CD11b-CD18 expression may underlie its impact on granulocyte function.