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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
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Surface modified polymeric nanoparticles for immunisation against equine strangles.

H F Florindo1, S Pandit, L M D Gonçalves

  • 1iMED.UL, Faculdade de Farmácia, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003 Lisboa, Portugal.

International Journal of Pharmaceutics
|October 15, 2009
PubMed
Summary
This summary is machine-generated.

Researchers developed stable poly(lactic acid) nanoparticles using polyvinyl alcohol, alginate, and glycolchitosan for Streptococcus equi antigen delivery. Surface modification enhanced sustained antigen release, showing promise for vaccine development.

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Area of Science:

  • Biomaterials Science
  • Vaccine Technology
  • Nanotechnology

Background:

  • Particulate vaccine development requires understanding physicochemical and biological properties.
  • Surface modification of nanoparticles is crucial for effective antigen delivery.

Purpose of the Study:

  • To develop and characterize stable, surface-modified poly(lactic acid) (PLA) nanoparticles.
  • To investigate the adsorption of Streptococcus equi enzymatic extract onto PLA nanoparticles modified with polyvinyl alcohol (PVA), alginate (ALG), and glycolchitosan (GCS).

Main Methods:

  • Nanoparticle formulation using PLA with PVA, ALG, or GCS surface modification.
  • Adsorption efficiency studies of S. equi proteins onto nanoparticles.
  • Physicochemical characterization including adsorption kinetics and desorption profiles.
  • Analysis of protein adsorption equilibrium using Freundlich model.

Main Results:

  • High adsorption efficiency (75-85%) achieved within 1 hour for all formulations.
  • No protein degradation observed during formulation.
  • Freundlich-type adsorption equilibrium confirmed with high regression coefficients (r² > 0.98).
  • Sustained protein release observed after an initial burst release; GCS modification showed prolonged release (20% at 30 days).

Conclusions:

  • Adsorption is a viable method for producing S. equi antigen carriers.
  • Surface-modified PLA nanoparticles demonstrate potential for effective vaccine delivery.
  • Glycolchitosan modification enhances sustained antigen release for improved vaccine efficacy.