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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: Jun 19, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

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Vectors for pulmonary gene therapy.

Johannes Geiger¹, Manish K Aneja, Carsten Rudolph

¹Department of Pediatrics, Ludwig-Maximilians-University Munich, Lindwurmstrasse 2a, 80337 Munich, Germany.

International Journal of Pharmaceutics

|October 15, 2009

Summary

Gene therapy shows promise for lung diseases, but efficient delivery and expression of therapeutic genes remain challenging. This review explores current viral and non-viral strategies for pulmonary gene therapy.

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Area of Science:

Pulmonary Medicine
Gene Therapy
Molecular Biology

Background:

Gene therapy is a promising approach for treating various lung diseases.
The lungs offer accessible targets for gene delivery via airways.
Challenges remain in achieving efficient transgene expression for therapeutic effect.

Purpose of the Study:

To review the current status of gene therapy strategies for lung diseases.
To discuss the prospects of viral and non-viral delivery systems for pulmonary gene therapy.

Main Methods:

Review of existing literature on pulmonary gene therapy.
Analysis of viral and non-viral gene delivery methods.
Discussion of challenges and future directions in the field.

Main Results:

Preclinical and early clinical studies demonstrate gene therapy's potential.
Efficient gene delivery and expression in lung tissues are significant hurdles.
Various viral and non-viral vectors are being investigated.

Conclusions:

Pulmonary gene therapy holds significant therapeutic potential.
Overcoming delivery and expression challenges is crucial for clinical success.
Continued research into novel viral and non-viral strategies is essential.