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Updated: Jun 19, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Postoperative cognitive dysfunction in the elderly.

Ramesh Ramaiah1, Arthur M Lam

  • 1Anesthesiology and Pain Medicine, University of Washington, Harborview Medical Center, Seattle, WA 98104-8009, USA. ramaiahr@u.washington.edu

Anesthesiology Clinics
|October 15, 2009
PubMed
Summary
This summary is machine-generated.

Elderly patients often experience postoperative cognitive decline (POCD), a memory impairment linked to aging. This review explores POCD causes, assessment, and anesthetic strategies for better cognitive outcomes in older adults.

Related Experiment Videos

Last Updated: Jun 19, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Area of Science:

  • Geriatric Medicine
  • Anesthesiology
  • Neuroscience

Background:

  • Postoperative cognitive decline (POCD) remains a significant concern in elderly patients despite advances in surgical and anesthetic care.
  • Increasing age is the primary risk factor for developing POCD, characterized by impaired memory and thinking.

Observation:

  • POCD is multifactorial, with its exact cause (surgery vs. general anesthesia) still under investigation.
  • Neuropsychological testing confirms the presence of cognitive impairment following surgery.

Findings:

  • This article comprehensively reviews the incidence, assessment methods, and consequences of POCD in the elderly population.
  • It also examines various anesthetic strategies aimed at mitigating cognitive decline and improving outcomes.

Implications:

  • Understanding the multifactorial nature of POCD is crucial for developing targeted prevention strategies.
  • Optimizing anesthetic management may play a key role in preserving cognitive function in older surgical patients.