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Related Experiment Video

Updated: Jun 19, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

The engineering of brown fat.

Mark Christian¹, Malcolm G Parker

¹Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK.

Journal of Molecular Cell Biology

|October 15, 2009

Summary

This summary is machine-generated.

Brown and white fat cells develop differently, with brown fat cells originating from muscle precursors. A specific protein complex (PR domain containing 16 and C/EBPbeta) drives brown fat development while inhibiting muscle cell growth.

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Last Updated: Jun 19, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

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Published on: March 28, 2013

Area of Science:

Adipose tissue biology
Cell differentiation
Developmental origins

Background:

Brown and white adipose tissues exhibit distinct developmental pathways.
Brown adipocytes originate from muscle precursor cells.

Purpose of the Study:

To elucidate the molecular mechanisms governing the lineage switch from muscle precursors to brown adipocytes.
To identify key transcription factors involved in brown fat differentiation.

Main Methods:

Investigated the role of PR domain containing 16 (PRDM16) and C/EBPbeta in adipogenesis.
Analyzed the transcriptional complex formation and its impact on cell fate decisions.

Main Results:

PRDM16 and C/EBPbeta form a crucial lineage-switching transcriptional complex.
This complex promotes brown adipocyte differentiation.
The complex simultaneously suppresses muscle cell differentiation.

Conclusions:

The PRDM16-C/EBPbeta complex is a key regulator of brown fat development from muscle precursors.
Understanding this mechanism offers insights into controlling adipose tissue expansion and energy expenditure.