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Updated: Jun 19, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

Serum leptin levels in patients undergoing carotid endarterectomy: a pilot study

Ioannis Bountouris1, Kosmas I Paraskevas, Michael Koutouzis

  • 1Red Cross Hospital, Athens, Greece.

Angiology
|October 15, 2009
PubMed

Insights

Serum leptin levels were lower in patients with symptomatic carotid artery disease compared to asymptomatic individuals. This suggests a potential link between reduced leptin and carotid artery symptoms.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Vascular Surgery

Background:

  • Elevated serum leptin is linked to cardiovascular events.
  • Leptin's role in carotid artery disease requires further elucidation.

Purpose of the Study:

  • To investigate the association between serum leptin levels and symptomatic carotid artery disease.
  • To explore the relationship between leptin, interleukin-6 (IL-6), and macrophage accumulation in patients undergoing carotid endarterectomy (CEA).

Main Methods:

  • A cohort of 74 patients undergoing CEA for >70% carotid artery stenosis was analyzed.
  • Serum leptin and IL-6 levels were measured.
  • Macrophage accumulation was assessed in symptomatic versus asymptomatic patients.

Main Results:

  • Symptomatic patients exhibited significantly lower serum leptin levels (7.1 +/- 1.3 ng/dL) compared to asymptomatic patients (14.4 +/- 4.7 ng/dL).
  • Symptomatic patients had higher IL-6 levels (4.3 +/- 1.7 pg/dL) and increased macrophage accumulation (0.7% +/- 0.1%) compared to asymptomatic patients.
  • Multivariate analysis confirmed serum leptin and IL-6 levels were independently associated with symptom presence.

Conclusions:

  • Serum leptin levels are decreased in patients with symptomatic carotid artery disease.
  • Lower leptin may be a marker for symptomatic carotid artery disease, warranting further investigation in larger cohorts.
Abstract

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