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Updated: Jun 19, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Interaction of MRI field gradients with the human body
1The Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK. paul.glover@Nottingham.ac.uk
Abstract:
In this review, the effects of low-frequency electromagnetic fields encountered specifically during magnetic resonance imaging (MRI) are examined. The primary biological effect at frequencies of between 100 and 5000 Hz (typical of MRI magnetic field gradient switching) is peripheral nerve stimulation, the result of which can be a mild tingling and muscle twitching to a sensation of pain. The models for nerve stimulation and how they are related to the rate of change of magnetic field are examined. The experimental measurements, and analytic and computational modelling work in this area are reviewed. The review concludes with a discussion of current regulation in this area and current practice as both are applied to MRI.
Insights
Low-frequency electromagnetic fields in magnetic resonance imaging (MRI) can cause peripheral nerve stimulation, leading to tingling or pain. This review examines MRI nerve stimulation models, experimental data, and current safety regulations.
Area of Science:
- Medical Physics
- Biophysics
- Neuroscience
Background:
- Magnetic Resonance Imaging (MRI) utilizes low-frequency electromagnetic fields.
- Gradient switching in MRI generates fields between 100 and 5000 Hz.
- These fields can induce biological effects, primarily peripheral nerve stimulation.
Purpose of the Study:
- To review the effects of low-frequency electromagnetic fields during MRI.
- To examine models of MRI-induced peripheral nerve stimulation.
- To discuss current regulations and practices concerning MRI safety.
Main Methods:
- Review of existing literature on nerve stimulation.
- Analysis of experimental measurements.
- Examination of analytical and computational modeling studies.
Main Results:
- Peripheral nerve stimulation is the primary biological effect of MRI's low-frequency fields.
- Stimulation can range from mild tingling to painful sensations.
- Models relate nerve stimulation to the rate of change of magnetic fields.
Conclusions:
- Understanding MRI-induced nerve stimulation is crucial for patient safety.
- Current regulations and practices aim to mitigate these effects.
- Further research may refine safety guidelines for MRI procedures.
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