Related Experiment Video
Updated: Jun 19, 2026

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
Published on: October 6, 2014
The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression
R Wäsch1, J A Robbins, F R Cross
1Department of Hematology and Oncology, University Medical Center, Freiburg, Germany. ralph.waesch@uniklinik-freiburg.de
Abstract:
Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation. The anaphase-promoting complex or cyclosome (APC/C) activated by Cdh1 coordinately eliminates positive cell-cycle regulators as well as inhibitors of differentiation, thereby coupling cell-cycle exit and differentiation. Misregulation of Cdh1 thus has the potential to promote both cell-cycle re-entry and either perturbed differentiation or dedifferentiation. In addition, APC/C(Cdh1) is required to maintain genomic stability. As a result, loss of Cdh1 can contribute to tumorigenesis in the form of proliferation of poorly differentiated and genetically unstable cells.
More Related Videos
06:12Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
07:26Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Related Concept Videos
Anaphase Promoting Complex
Anaphase Promoting Complex
Abnormal Proliferation
Inhibition of Cdk Activity
Separation of Sister Chromatids
At the onset of anaphase, separase, a proteolytic enzyme, is...
DNA Damage can Stall the Cell Cycle