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Cognitive impairment in Parkinson's disease without dementia: subtypes and influences of age

Jae Woo Kim1, Sang Myung Cheon, Min Jeong Park

  • 1Department of Neurology, College of Medicine, Dong-A University, Busan, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|October 15, 2009
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) is frequent in Parkinson's disease (PD), affecting 40.4% of patients. Age is a significant risk factor, particularly for executive dysfunction subtypes of PD-MCI.

Area of Science:

  • Neurology
  • Neuropsychology
  • Geriatrics

Background:

  • Cognitive impairments are prevalent in Parkinson's disease (PD).
  • These impairments often do not significantly affect daily activities in early stages.
  • Understanding the frequency and subtypes of mild cognitive impairment (MCI) in PD is crucial.

Purpose of the Study:

  • Determine the frequency of Parkinson's disease mild cognitive impairment (PDMCI) in nondemented PD patients.
  • Identify the subtypes of PDMCI.
  • Evaluate the influence of age on PDMCI subtypes.

Main Methods:

  • 141 nondemented PD patients underwent comprehensive neuropsychological assessments.
  • PDMCI was defined by impaired performance in at least one of five cognitive domains (attention, language, visuospatial, memory, executive functions).
  • Age influence was assessed by comparing younger and older patient groups.

Main Results:

  • 40.4% of patients were diagnosed with PDMCI.
  • PDMCI patients had significantly higher age at assessment and disease onset.
  • Amnestic PDMCI was most common, followed by visuospatial, linguistic, executive, and attention subtypes.
  • Older patients showed higher PDMCI frequency across all subtypes, with executive function most affected by age.

Conclusions:

  • MCI is common and diverse in PD.
  • Age is a key risk factor for PDMCI, especially executive subtypes.
  • The concept of MCI should be integrated into PD management.
Keywords:
Parkinson's diseaseParkinson's disease dementiamild cognitive impairment

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