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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Relationships between 24-Hour Blood Pressures, Subcortical Ischemic Lesions, and Cognitive Impairment

Jung Eun Kim1, Ji Soo Shin, Jee Hyang Jeong

  • 1Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|October 15, 2009
PubMed

Insights

Subcortical vascular dementia (SVaD) is linked to a loss of normal nocturnal blood pressure (BP) dipping. Addressing this and BP variability may help prevent SVaD.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Subcortical vascular dementia (SVaD) treatment primarily involves blood pressure (BP) control.
  • Previous research on diurnal BP rhythm in subcortical ischemic vascular cognitive impairment yielded inconclusive results.

Purpose of the Study:

  • To compare 24-hour ambulatory BP (ABP) values in patients with SVaD, mild cognitive impairment (SvMCI), and controls.
  • To investigate the relationship between diurnal BP patterns and cognitive impairment.

Main Methods:

  • Recruited 42 SVaD patients, 37 SvMCI patients, and 30 controls.
  • Utilized brain MRI, MR angiography, neuropsychological testing, and 24-hour ABP monitoring.

Main Results:

  • Prevalence of 'nondippers' (loss of nocturnal BP dipping) was significantly higher in SVaD and SvMCI groups compared to controls.
  • Loss of nocturnal BP dipping was strongly associated with SVaD (OR, 4.827).

Conclusions:

  • SVaD is associated with disrupted nocturnal BP dipping, increased pulse pressure, and systolic BP variability.
  • Managing these BP factors may be crucial for SVaD prevention, beyond general BP reduction.
Abstract

Keywords:
24-hour blood pressure valuessubcortical vascular dementiasubcortical vascular mild cognitive impairment

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