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In Vivo Electrophysiological Measurements on Mouse Sciatic Nerves
11:07

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Published on: April 13, 2014

Reference data for commonly used sensory and motor nerve conduction studies.

Michael Benatar1, Joanne Wuu, Limin Peng

  • 1Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, Suite 6000, 101 Woodruff Circle, Atlanta, Georgia 30322, USA. michael.benatar@emory.edu

Muscle & Nerve
|October 15, 2009
PubMed
Summary

This study generated essential reference data for nerve conduction studies (NCSs) in routine electrodiagnostics. Age and gender adjustments were key for accurate sensory and motor nerve amplitude and latency data.

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Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Nerve conduction studies (NCSs) are crucial in electrodiagnostic practice.
  • Establishing reliable reference data is essential for accurate diagnosis.

Purpose of the Study:

  • To generate comprehensive reference data for common sensory and motor NCSs.
  • To identify necessary covariate adjustments for accurate reference values.

Main Methods:

  • Collected NCS data from 296 neurologically normal control subjects.
  • Utilized quantile regression to estimate various percentiles for amplitudes and latencies.
  • Studied thirteen sensory and motor nerves in upper and lower limbs.

Main Results:

  • Sensory and motor amplitudes required age adjustment; F-wave latencies required gender adjustment.
  • Sample sizes of 100 and 190 allowed estimation down to the 4th and 2nd percentiles, respectively.
  • Increased sample size to 296 did not enable estimation of more extreme percentiles.

Conclusions:

  • Developing reference data necessitates careful subject selection, adequate sample size, covariate adjustment, and appropriate statistical methods.
  • Reference data with high variability or absent potentials require cautious interpretation.
  • Presented clinically applicable reference percentiles await evaluation in disease populations for diagnostic utility.