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Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
Published on: September 6, 2024
How early do parent concerns predict later autism diagnosis?
Sally Ozonoff1, Gregory S Young, Mary Beth Steinfeld
1M.I.N.D. Institute, University of California Davis Health System, Sacramento, CA 95817, USA. sally.ozonoff@ucdmc.ucdavis.edu
Insights
Parental concerns about developmental milestones by 12 months can predict autism spectrum disorder (ASD) diagnosis. Early identification through parental feedback aids in timely intervention and surveillance for at-risk infants.
Area of Science:
- Developmental Pediatrics
- Autism Spectrum Disorder Research
- Child Psychology
Background:
- Parental concerns regarding child development are crucial indicators.
- Early identification of developmental delays can significantly impact intervention outcomes.
- Autism Spectrum Disorder (ASD) diagnosis relies on behavioral and developmental assessments.
Purpose of the Study:
- To investigate the link between parental concerns about infant development and later ASD diagnostic outcomes.
- To determine the predictive value of parental concerns in the first 18 months of life for ASD diagnosis.
- To assess the utility of parental feedback in identifying infants requiring closer developmental monitoring.
Main Methods:
- Prospective, longitudinal study design tracking infants at high and low risk for ASD.
- Collection of parental developmental concerns at infant ages 6, 12, and 18 months.
- Diagnostic assessment for ASD conducted at 36 months of age.
Main Results:
- Parents of children later diagnosed with ASD reported significantly more autism-related concerns by 12 months.
- Parental concerns at 12 months correlated with developmental status and autism symptoms, predicting later ASD diagnosis.
- Parental concerns at 6 months showed limited predictive value for ASD outcome.
Conclusions:
- Probing parental concerns about development is a valuable tool for early identification of children needing enhanced surveillance.
- Parental insights can supplement clinical assessments in identifying infants at risk for ASD.
- Findings support the American Academy of Pediatrics' recommendations for developmental monitoring.
Objective:
To study the relationship between parent concerns about development in the first year and a half of life and later autism diagnostic outcomes.
Method:
Parent concerns about development were collected for infants at high and low risk for autism, using a prospective, longitudinal design. Parents were asked about developmental concerns at study intake and when their infant was 6, 12, and 18 months. Infants were then followed up until 36 months, when diagnostic status was determined.
Results:
By the time their child was 12 months, parents who have an older child with autism reported significantly more concerns in autism spectrum disorders-related areas than parents of children with typical outcomes. These concerns were significantly related to independent measures of developmental status and autism symptoms and helped predict which infants would later be diagnosed with autism or autism spectrum disorders. At 6 months, however, the concerns of parents who have an older child with autism do not predict outcome well.
Conclusion:
Explicitly probing for parent concerns about development is useful for identifying children in need of closer monitoring and surveillance, as recommended by the American Academy of Pediatrics.
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