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Lyophilization of biological standards

Paul Matejtschuk1

  • 1Centre for Biological Reference Materials, National Institute for Biological Standards & Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK. pmatejt@nibsc.ac.uk

Cryo Letters
|October 16, 2009
PubMed

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Sublimation is the direct transformation of a solid to a gaseous state. For instance, at standard pressure and room temperature, solid carbon dioxide sublimes to gaseous carbon dioxide. The phase diagram depicts the conditions required for sublimation. This process occurs at the solid-gas phase boundary and is not observed above the triple point of the substance. The reverse of sublimation is called deposition, where a gaseous substance condenses directly into a solid. Sublimation and...