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Updated: Jun 19, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Two cases of complex sleep apnea syndrome]
Takahiro Yamada1, Taichiro Arimoto, Yasunori Koyama
1Department of Pulmonary Medicine, Kyoto Prefectural University of Medicine.
Summary
Complex sleep apnea syndrome (comp. SAS) is a sleep disorder that can worsen with CPAP therapy. While CPAP helped one patient, Adaptive Servo-Ventilation (ASV) was needed for another, showing ASV can be effective for comp. SAS.
Area of Science:
- Sleep Medicine
- Respiratory Physiology
Background:
- Continuous positive airway pressure (CPAP) is a standard treatment for obstructive sleep apnea syndrome (OSAS).
- Complex sleep apnea syndrome (comp. SAS) is a condition where central sleep apnea emerges or worsens during CPAP therapy for OSAS.
- The pathophysiology and optimal treatment strategies for comp. SAS remain incompletely defined.
Observation:
- Two cases of comp. SAS were treated with CPAP therapy.
- Case 1 showed symptom improvement and reduced central apneas after one year of CPAP, confirmed by polysomnography (PSG).
- Case 2 did not improve with CPAP therapy after one year.
Findings:
- CPAP therapy can be effective for some patients with comp. SAS.
- Adaptive Servo-Ventilation (ASV) therapy led to symptom improvement and reduced central apneas in a patient with comp. SAS refractory to CPAP.
- ASV may be a suitable alternative treatment for comp. SAS when CPAP is ineffective.
Implications:
- These findings suggest that comp. SAS may require individualized treatment approaches.
- ASV therapy presents a viable therapeutic option for select patients with comp. SAS.
- Further research is warranted to elucidate the mechanisms of comp. SAS and optimize treatment algorithms.
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