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A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Hepatitis C virus is infrequently evaluated and treated in an urban HIV clinic population

John D Scott1, Anna Wald, Mari Kitahata

  • 1Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA. jdscott@u.washington.edu

AIDS Patient Care and Stds
|October 16, 2009
PubMed

Insights

Many HIV/hepatitis C virus (HCV) coinfected patients received delayed HCV treatment. Less than half were evaluated, and only 16% received treatment, highlighting significant delays in care.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection is a significant concern for patients coinfected with human immunodeficiency virus (HIV).
  • Timely HCV evaluation and treatment are crucial for managing coinfection and improving patient outcomes.
  • Understanding treatment trends in this population is essential for optimizing clinical care pathways.

Purpose of the Study:

  • To analyze time trends and rates of HCV evaluation and treatment among HIV/HCV coinfected patients.
  • To identify factors associated with the time to HCV evaluation and treatment.
  • To assess the effectiveness of HCV treatment in this cohort.

Main Methods:

  • Retrospective cohort study design.
  • Inclusion of HIV/HCV coinfected patients seen between January 1, 1997, and October 30, 2004.
  • Application of survival analysis and Cox proportional hazards modeling.

Main Results:

  • Out of 248 eligible patients, 108 (44%) were evaluated for HCV treatment, with a median time to evaluation of 2.98 years.
  • Only 17 (16%) of evaluated patients received interferon and/or ribavirin, with a median time to treatment of 1.39 years post-evaluation.
  • A sustained virologic response was achieved in 6 of 17 treated patients (35% of treated, 2.4% of original cohort).

Conclusions:

  • Approximately half of HIV/HCV coinfected patients in an HIV specialty clinic were evaluated for HCV therapy, and 16% received treatment.
  • Significant delays were observed, with a median time to treatment exceeding 4 years from HCV diagnosis.
  • Further research is warranted to identify and address barriers to timely HCV evaluation and treatment in coinfected patients.

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