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Related Experiment Video

Updated: Jun 19, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Radiation therapy for intrahepatic malignancies.

Allison M Quick1, Simon S Lo, Nina A Mayr

  • 1Department of Radiation Oncology, Arthur G James Cancer Hospital, Ohio State University Medical Center, 300 West 10th Avenue, Ste 088A, Columbus, OH 43210, USA. allison.quick@osumc.edu

Expert Review of Anticancer Therapy
|October 16, 2009
PubMed
Summary

Radiation therapy is now a viable option for liver cancers like hepatocellular carcinoma and metastasis, thanks to advanced techniques improving liver tolerance and treatment outcomes.

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Area of Science:

  • Hepatobiliary oncology
  • Radiation oncology

Background:

  • Historically, liver's low radiation tolerance limited its use in treating intrahepatic malignancies.
  • Hepatocellular carcinoma and liver metastasis were challenging to manage with radiation therapy.

Purpose of the Study:

  • To review advancements in radiation delivery techniques for intrahepatic malignancies.
  • To discuss the clinical applications and outcomes of modern radiation therapy in liver cancer management.

Main Methods:

  • Review of medical literature focusing on advanced radiation therapy techniques.
  • Discussion of 3D conformal radiation therapy, intensity-modulated radiation therapy, image-guided radiation therapy, stereotactic body radiation therapy, proton-beam therapy, and internal radiation therapy.
  • Analysis of clinical studies evaluating response rates and toxicity profiles.

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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

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Last Updated: Jun 19, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Main Results:

  • Advanced radiation techniques allow for partial and selective irradiation of the liver.
  • These techniques demonstrate promising response rates in treating intrahepatic malignancies.
  • Improved toxicity profiles have been observed with modern radiation delivery methods.

Conclusions:

  • Radiation therapy is increasingly effective for hepatocellular carcinoma and liver metastasis.
  • Modern radiation techniques have overcome previous limitations of liver tolerance.
  • Further research and clinical application of these techniques are warranted for liver cancer treatment.