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Updated: Jun 19, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

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[Langerhans cell histiocytosis].

L Ben Slama1, B Ruhin, A Zoghbani

  • 1Service de chirurgie maxillofaciale et stomatologie, hôpital Adulte de la Pitié-Salpêtrière, université Pierre-et-Marie-Curie Paris-6, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. lbenslama@noos.fr

Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|October 16, 2009
PubMed
Summary

Langerhans cell histiocytosis (LCH) is a rare childhood disorder involving abnormal Langerhans cell proliferation. Diagnosis uses anti-CD1a immunolabeling, with varied presentations from bone lesions to acute malignant disease.

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Area of Science:

  • Pediatric Pathology
  • Immunohistochemistry
  • Oncology

Context:

  • Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a rare clonal disorder primarily affecting children.
  • It involves the proliferation of non-functional Langerhans cells, presenting diverse histological features.

Purpose:

  • To define Langerhans cell histiocytosis (LCH) and its diagnostic markers.
  • To outline the spectrum of clinical presentations and associated syndromes.

Summary:

  • LCH is characterized by clonal proliferation of Langerhans cells, with diagnosis confirmed via anti-CD1a immunolabeling.
  • Clinical manifestations vary widely, encompassing localized bone disease (eosinophilic granuloma), chronic disseminated forms (Hand-Schüller-Christian disease), and acute, aggressive presentations (Abt-Letterer-Siwe disease).

Related Experiment Videos

Last Updated: Jun 19, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Impact:

  • Provides a concise overview of LCH for clinicians and researchers.
  • Highlights the importance of immunolabeling in LCH diagnosis.
  • Clarifies the relationship between distinct clinical syndromes under a single pathogenic process.