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Updated: Jun 19, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Factor V Leiden as risk factor for unexplained stillbirth--a population-based nested case-control study.

Leena M Hiltunen¹, Hannele Laivuori, Anna Rautanen

¹Department of Hemostasis, Finnish Red Cross Blood Service, Helsinki, Finland. leena.hiltunen@bts.redcross.fi

Thrombosis Research

|October 16, 2009

Summary

This summary is machine-generated.

Genetic factor FV Leiden significantly increases the risk of unexplained stillbirth, particularly when placental lesions are present. This finding highlights the importance of considering thrombophilia in stillbirth risk assessment.

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Last Updated: Jun 19, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Area of Science:

Obstetrics and Gynecology
Genetics
Perinatal Medicine

Background:

Stillbirth, though uncommon, carries a significant emotional burden.
Thrombophilia is a suspected risk factor for stillbirth, but population-based evidence is limited.
Factor V (FV) Leiden is a common genetic thrombophilia.

Purpose of the Study:

To investigate the association between selected genetic and acquired thrombophilia parameters and the risk of unexplained stillbirth.
To assess the specific role of FV Leiden in unexplained stillbirth.

Main Methods:

A population-based nested case-control study involving 100,000 pregnancies in Finland.
Strict criteria were used to identify 44 cases of unexplained stillbirth (intrauterine fetal death ≥22 weeks gestation) and 766 controls.
Exclusion criteria included stillbirths due to congenital anomalies, cord complications, or infections.

Main Results:

FV Leiden was associated with a 3.8-fold increased risk of unexplained stillbirth.
The risk was higher for unexplained stillbirth with placental lesions (10.8-fold increase).
Trends suggested increased risk with advanced maternal age and smoking, but not with BMI, education, or parity.

Conclusions:

This population-based study confirms a significant association between FV Leiden and unexplained stillbirth.
The findings underscore the importance of screening for thrombophilia in cases of unexplained stillbirth.