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Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
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Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex

Elena Isaeva1, Dmytro Isaev, Rustem Khazipov

  • 1Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA. olena.isaeva@gmail.com

Epilepsy Research
|October 16, 2009
PubMed

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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...