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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Updated: Jun 19, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cells in atopic dermatitis.

Toshiaki Kawakami1, Tomoaki Ando, Miho Kimura

  • 1Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. toshi@liai.org

Current Opinion in Immunology
|October 16, 2009
PubMed
Summary
This summary is machine-generated.

Mast cells, activated by IgE receptors, are key players in allergic reactions and are implicated in atopic dermatitis. This review synthesizes current research on mast cell involvement in this common skin disease.

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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Mast cells are central to immediate hypersensitivity reactions via Fc epsilon RI activation.
  • Recent discoveries highlight diverse functions of mast cells beyond allergy.
  • Atopic dermatitis pathogenesis is linked to mast cell mediators, IgE, and mast cell counts.

Purpose of the Study:

  • To review recent advancements in understanding atopic dermatitis.
  • To synthesize current knowledge on the role of mast cells in atopic dermatitis.
  • To explore potential mechanisms of mast cell involvement in disease.

Main Methods:

  • Literature review of recent scientific progress.
  • Analysis of animal models for atopic dermatitis research.
  • Synthesis of data on mast cell activation and mediators.

Main Results:

  • Mast cells are implicated in atopic dermatitis due to their inflammatory mediators.
  • Fc epsilon RI activation is a key pathway for mast cell effector functions.
  • Elevated IgE and mast cell numbers are common in atopic dermatitis patients.

Conclusions:

  • Mast cells are strongly implicated in the pathogenesis of atopic dermatitis.
  • Further research is needed to fully elucidate mast cell mechanisms in this disease.
  • Understanding mast cell roles may offer new therapeutic strategies for atopic dermatitis.