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Updated: Jun 19, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Vascular wall invasion in neurofibromatosis-induced aortic rupture
John L Falcone1, Michael R Go, Donald T Baril
1Division of Vascular Surgery, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.
Abstract:
Neurofibromatosis type 1 (NF-1) is an autosomal dominant disease primarily characterized by cutaneous café au lait macules, benign neurofibromas, and iris hamartomas. A spectrum of vascular abnormalities is associated with NF-1. We present a case of a 49-year-old female with NF-1 and spontaneous rupture of the infrarenal aorta caused by invasion of a neurofibroma and treated with endovascular stent grafting.
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