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Updated: Jun 19, 2026
Mechanical Testing of Mouse Carotid Arteries: from Newborn to Adult
Published on: February 23, 2012
Finite element model of the patched human carotid
Alexey V Kamenskiy1, Iraklis I Pipinos, Anastasia S Desyatova
1Department of Engineering Mechanics, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.
Introduction:
The hemodynamic effects of carotid artery patching are not well known. Our objective was to develop a fluid-solid finite element model of the endarterectomized and patched carotid artery.
Methods:
Hyperelastic materials parameters were determined from studies of 8 cadaveric carotids. Blood flow characteristics were based on intraoperative data from a patient undergoing endarterectomy. Wall shear stress, cyclic strain and effective stress were computed as hemodynamic parameters with known association with endothelial injury, neointimal hyperplasia and atherogenesis.
Results:
Low wall shear stress, high cyclic strain and high effective stress were identified diffusely in the carotid bulb, at the margins around the patch and in the flow divider.
Conclusion:
Endarterectomy and polytetrafluoroethylene patching produce considerable abnormalities in the hemodynamics of the repaired carotid. Advanced mechanical modeling can be used to evaluate different carotid revascularization approaches to obtain optimized biomechanical and hemodynamic results for the care of patients with carotid bifurcation disease.
