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Updated: Jun 19, 2026
Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
Published on: January 19, 2014
Mapping of quantitative trait loci affecting classical scrapie incubation time in a population comprising several
Carole R Moreno1, Katayoun Moazami-Goudarzi, Stephanie Briand
1INRA, UR631, Amélioration Génétique des Animaux, BP52627, 31326 Castanet-Tolosan, France. Moreno@toulouse.inra.fr
Abstract:
Although susceptibility to scrapie is largely controlled by the PrP gene, the role of other genes that affect scrapie resistance in sheep is now confirmed. Following the detection of quantitative trait loci (QTL) on chromosomes 6 and 18 in a half-sib family with an ARQ/VRQ susceptible PrP genotype, the whole pedigree of a naturally infected flock was investigated to confirm these QTL regions in different PrP genotypes. The present study has allowed us to confirm the QTL on chromosome 18, and to demonstrate the QTL effects in several PrP genotypes.
