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Related Experiment Video

Updated: Jun 19, 2026

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

CCR5 down-regulates osteoclast function in orthodontic tooth movement.

I Andrade¹, S R A Taddei, G P Garlet

¹Department of Orthodontics, Faculty of Dentistry, Pontifícia Universidade Católica de Minas Gerais, Av. Dom José Gaspar 500, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil. ildeu_andrade@yahoo.com.br

Journal of Dental Research

|October 16, 2009

Summary

The CCR5 receptor may regulate alveolar bone resorption during orthodontic tooth movement. CCR5-deficient mice showed increased osteoclast activity and greater tooth movement, suggesting CCR5 down-regulates bone resorption.

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Published on: March 18, 2019

Area of Science:

Immunology
Orthodontics
Bone Biology

Background:

Orthodontic tooth movement involves chemokine production and leukocyte infiltration in the periodontium.
CCL5 is implicated in osteoclast recruitment and activation, key processes in bone remodeling.

Purpose of the Study:

To investigate the influence of the CCR5 receptor on leukocyte influx and bone remodeling during orthodontic tooth movement.
To determine if CCR5 deficiency affects the rate and extent of tooth movement.

Main Methods:

Orthodontic appliances were applied to wild-type (WT) and CCR5-deficient (CCR5(-/-)) mice.
Real-time PCR was used to evaluate gene expression of bone remodeling mediators in periodontal tissues.
Osteoclast numbers and expression of specific bone remodeling markers were quantified.

Main Results:

CCR5(-/-) mice exhibited significantly higher numbers of TRAP-positive osteoclasts and expression of cathepsin K, RANKL, and MMP13.
Expression of osteoblastic markers (RUNX2, osteocalcin) and bone resorption regulators (IL-10, OPG) was lower in CCR5(-/-) mice.
CCR5(-/-) mice demonstrated a greater amount of tooth movement after 7 days of mechanical loading.

Conclusions:

The CCR5 receptor appears to play a role in regulating alveolar bone resorption during orthodontic tooth movement.
CCR5 deficiency leads to enhanced osteoclast activity and increased tooth movement, suggesting CCR5 acts as a down-regulator of bone resorption in this context.